29th May - Saturday
|
Arrivals |
| 15.00 - 17.00 |
Registration |
| 17.00 - 17.30 |
Welcome and Opening
Janez Plavec
Stanislav Pejovnik, Rector Magnificus, University of Ljubljana |
Afternoon session in conjunction with WG2 of COST MP0802 (Chair: Joze Kobe)
| 17.30 - 18.00 |
Jyoti Chattopadhyaya
Some New Aspects of Conformationally-constrained Polynucleotides (DNA and RNA) |
| 18.00 - 18.30 |
Zhen Xi, Zicai Liang
RNA Stability and RNAi Enhancement |
| 18.30 - 19.00 |
Aaron E. Engelhart, Ozgul P. Cetinkol, Irena Mamajanov, Nicholas V. Hud
Thermodynamic and structural studies of ligand and solvent effects on the stability of various nucleic acid secondary structures |
| 19.00 - 22.00 |
Poster session / Refreshments |
30th May - Sunday
Morning session I (Chair: Jyoti Chattopadhyaya)
| 9.00 - 9.30 |
Vidhi Maheshwari, Patricia Marzilli, Luigi G. Marzilli
Conformations of the 17-membered Ptd(GpG) Macrocyclic Ring Formed by Pt Anticancer Drugs with DNA. Effect of Carrier Ligand Bulk, Including Model Having a Goldilocks-like Carrier Ligand |
| 9.30 - 10.00 |
Giovanni Natile
Different processing of DNA adducts formed by platinum compounds with enantiomeric amine ligands |
| 10.00 - 10.30 |
Naoki Sugimoto
Stabilization and Function of Nucleic Acids under Molecular Crowding Conditions |
| 10.30 - 11.00 |
Coffeee Break |
Morning session II (Chair: Piet Herdewijn)
| 11.00 - 11.30 |
Sarah C. Zimmermann, Joshua M. Sadler, Katherine Seley-Radtke
Exploring Structural Diversity in Nucleoside Drug Design |
| 11.30 - 12.00 |
Mladen Mintas
The new pyrimidine, purine and 1,2,4-triazole derivatives of L-ascorbic acid: synthesis, cytostatic and antiviral activity potency evaluations |
| 12.00 - 12.30 |
Silvana Raic-Malic
Non-natural nucleoside analogues for noninvasive monitoring of tumor cells using positron emission tomography (PET) |
| 12.30 - 13.00 |
Joze Kobe
From Non-natural Bases and Nucleosides to their incorporation into ODNs forming Inter Molecular Quadruplexes |
| 13.00 - 15.00 |
Lunch |
Afternoon session I (Chair: Janez Mavri)
| 15.00 - 15.30 |
Jiri Sponer
Molecular Dynamics Simulations of Nucleic Acids |
| 15.30 - 16.00 |
Modesto Orozco
Exploring DNA folding and unfolding from molecular dynamics simulations |
| 16.00 - 16.30 |
Jelena Tamuliene, Mindaugas Leonas Balevicius
Electric Field Gradient of Several Modified Adenine-Thymine pairs. Ab initio study |
| 16.30 - 17.00 |
Coffee Break |
Afternoon session II (Chair: Mateus Webba da Silva)
| 17.00 - 17.30 |
Lea Spindler
G-wires from mononucleosides and short G-rich oligonucleotides |
| 17.30 - 18.00 |
Alexandro Membrino, Luigi E. Xodo
Control of HRAS Transcription and Rationale Design of G4-Decoys for Cancer Therapy |
| 18.00 - 18.30 |
Iztok Prislan, Jurij Lah, Matija Milanic, Gorazd Vesnaver
Folding and unfolding transitions of d(G4T4G3) in the presence of K+ ions |
| 18.30 - 19.00 |
Kinga Majchrzak, Damian Smuga, Elzbieta Sochacka, Beata Kocon-Rebowska, Barbara Mikolajczyk, Barbara Nawrot
Deoxyribozyme 10-23 with extended catalytic properties |
| 19.00 - 22.00 |
Dinner at hotel Sabotin |
31st May - Monday
Morning session I in conjunction with WG2 of COST MP0802 (Chair: Lea Spindler)
| 9.00 - 9.30 |
Mateus Webba da Silva
Glycosidic Bond Angles to Understand and Control Folding of Nucleic Acid Quadruplexes |
| 9.30 - 10.00 |
Aldo Galeone, Veronica Esposito, Antonella, Virgilio, Giuseppe Citarella, Alfonso Mangoni
Studies of heterochiral oligonucleotides forming quadruplex structures |
| 10.00 - 10.30 |
Primoz Sket, Janez Plavec
Guanine-rich DNA sequences: Structures and cation interactions |
| 10.30 - 11.00 |
Coffeee Break |
Morning session II (Chair: Nicholas V. Hud)
| 11.00 - 11.30 |
Dorota Gudanis, Ryszard Kierzek, Zofia Gdaniec
Guanosine modification alters the strands orientation of the RNA tetraplex composed of trinucleotide CGG repeats |
| 11.30 - 12.00 |
Gavin Collie, Stephen Neidle, Gary Parkinson, Shozeb Haider
A Crystallographic and Modeling Study of a Human Telomeric RNA (TERRA) Quadruplex |
| 12.00 - 12.30 |
Sandro Cosconati, Luciana Marinelli, Roberta Trotta, Stefano De Tito, Bruno Pagano, Concetta Giancola, Luciano Mayol, Ettore Novellino, Antonio Randazzo
Structural and Conformational Requisites in DNA Quadruplex Groove Binding |
| 12.30 - 13.00 |
Gavin Collie, Stephen Neidle, Silbia Sparapani, Gary Parkinson
First crystal structure of a telomeric RNA quadruplex-ligand complex shows a unique mode of ligand binding |
| 13.00 - 15.00 |
Lunch |
Afternoon session I (Chair: Antonio Randazzo)
| 15.00 - 15.30 |
Gyula Batta, Pal Herczegh, Delia Picone, Marta Bruix, Katalin E. Kover
NMR Methods to Disclose Structure and Dynamics of G4 Self Assemblies and RNases |
| 15.30 - 16.00 |
Valerie Gabelica
Mass Spectrometry of G-quadruplexes |
| 16.00 - 16.30 |
Il Joon Lee, Jeong Wu Yi, Byeang Hyean Kim
Nucleic Acid Sensing: Quencher-free Molecular Beacons (Qf-MB) and Fluorescent Oligonucleotide Probes |
| 16.30 - 17.00 |
Coffee Break |
Afternoon session II (Chair: Barbara Nawrot)
| 17.00 - 17.30 |
Dimitra Markovitsi
DNA fluorescence: from duplexes to quadruplexes |
| 17.30 - 18.00 |
Piet Herdewijn
Towards a genetic enclave through the chemical modification of nucleotides and nucleic acids |
| 18.00 - 18.30 |
Andreas Marx
Chemical Biology of DNA Replication |
| 18.30 - 19.00 |
Leif A. Kirsebom, Shiying Wu, Stefan Trobro, Yu Chen
RNase P mediated catalysis - new insights |
| 19.00 |
Dinner and visit to wine cellar |