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PROGRAM

Programme will consist of Lectures, Scientific Discussions and Group Meetings.

Programme Outline:

timetable

Programme Outline PDF: pdf

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Programme
Tuesday, May 8
13.00 Arrival and Registration
  Advancements of Young Bio-NMR Group
  Jozef Lewandowski (Chair)
14.00 – 14.20 Lidija Kovačič: Probing the allosteric states of the lactose repressor protein
14.20 – 14.40 Han Sun: Towards Bijvoet in solution: new NMR methods for studying stereochemistry of challenging natural products
14.40 – 15.00 Robert Schneider: Folding and binding of the disordered tail of Sendai virus nucleoprotein to its partner studied by CPMG relaxation dispersion spectroscopy
15.00 – 15.30 Coffee Break
15.30 – 15.50 Ewen Lescop: NMR spectroscopy reveals the closed and compact conformation of the 70kDa human cytochrome P450 reductase in its oxidized state
15.50 – 16.10 Delia Picone: Structural and dynamical features of the two BS-RNase isoforms: insights for 3D domain swapping
16.10 – 16.30 Mats Wikström: Biophysical and structural studies of a novel SUMO-binding Zinc finger from the Ubiquitin ligase HERC2
16.30 – 16.50 Stefano Ricagno: Studying amyloidogenic beta-2 microglobulin: the monomer, the oligomers and the fibrils
   
17.00 – 19.00 Importance of Research Infrastructures: Potential of NMR in challenges ahead, opening of symposium
  Franci Demšar, Director, Slovenian Research Agency
  Ivano Bertini, Coordinator of the Bio-NMR Project, Magnetic Resonance Center (CERM) at the University of Florence, Italy
  Carlo Rizzuto, President, Elettra Laboratory, Sincrotrone Trieste, Italy
  Matjaž Polak, EN-FIST Centre of Excelence, Slovenia
  Janez Plavec, Slovenian NMR Centre, National Institute of Chemistry, Slovenia
19.00 – 21.00
 Welcome Reception Dinner
21.00
User Meeting Local Operator Meeting
Wednesday, May 9
  Large functional systems
  Harald Schwalbe (Chair)
9.00 – 9.30 Christian Griesinger: Protein dynamics of globular proteins and IDPs
9.30 – 10.00 Lucio Frydman: Hyperpolarized NMR to follow metabolic process: Principles and method developments
10.00 – 10.30 Michael Sattler: NMR studies of molecular recognition and dynamics of (large) protein complexes in solution
10.30 – 11.00 Coffee Break
11.00 – 11.30 Lucia Banci: NMR in mechanistic systems biology: from structures to function
11.30 – 12.00 Francesco Luigi Gervasio: Understanding the DGF-flip in cSrc and Abl tyrosine kinases through experimentally-validated free energy calculations
12.00 – 12.30 Stephan Grzesiek: Hydrogen bonds and other protein interactions studied by novel NMR methods
12.30 – 13.00 Göran Karlsson: Eliminating limitations in labelling and data acquisition
13.00 Lunch
  General Assembly
14.30 – 15.00 Brigitte Sambain
15.00 – 15.15 Ivano Bertini: Presentation of the Bio-NMR Project
15.15. – 15.25 Harald Schwalbe: Presentation of Transnational Access activity
15.25 – 15.35 Astrid Gräslund: On the international evaluation panel
15.35 – 15.55 Henriette Molinari: Representative of Bio-NMR users
15.55 – 16.25 Marcellus Ubbink: Protein interactions studied with paramagnetic NMR
16.25 – 16.55 Coffee Break
16.55 – 17.05 Rolf Boelens: Presentation of Joint Research Activities
17.05 – 17.35 Beat Meier: Scientific presentation
17.35 – 17.45 Claudio Luchinat: Presentation of Networking Activity
17.45 – 18.05 Antonio Rosato: Other related activity: WeNMR
18.05 – 18.20 Lucia Banci: Perspectives of Bio-NMR within Biological and Medical Sciences' Research Infrastructures
   
19.00 Dinner
Thursday, May 10
  Improving structure determination by solid-state NMR
  Beat Meier (Chair)
9.00 – 9.30 Lyndon Emsley: Protein NMR crystallography
9.30 – 10.00 Niels Christian Nielsen: Efficient coherence transfers in biological solid-state NMR
10.00 – 10.30 Adam Lange: Atomic model of the type III secretion system needle
10.30 – 11.00 Coffee Break
11.00 – 11.30 Enrico Ravera: On the use of sedimented solute NMR
11.30 – 12.00 Klaartje Houben: NMR studies on a stress-related plant membrane protein family
12.00 – 12.30 Ulrich Günther: Metabolic Flux Analysis - A new NMR Approach to Monitor the State of Cancer Cells and Organisms
12.30 – 13.00 Frank Engelke: Spatial millimeter wave field distributions in DNP MAS NMR probes
13.00 Lunch
   
  Optional tutorials
15.00 – 15.00 Karolis Lesickas: Introduction to python programming: a tool for data handling and workflow optimization
15.00 – 15.30 Vidmantas Brukštus: Animating structural biology: Introduction to 3D modeling and animation techniques
  Poster Session and Mid-term Reviews
16.00 – 18.00  
   
19.00 Dinner
Friday, May 11
  High sensitivity and fast NMR
  Claudio Luchinat (Chair)
9.00 – 9.30 Astrid Gräslund:NMR studies of the amyloid β peptide involved in Alzheimer's disease: molecular interactions, secondary structure conversions and aggregation
9.30 – 10.00 Ēriks Kupče: Parallel receivers and compressive sensing in multidimensional NMR
10.00 – 10.30 Bernhard Brutscher: Characterization of transiently populated folding intermediates by real-time 2D and 3D NMR spectroscopy
10.30 – 11.00 Coffee Break
11.00 – 11.30 Wiktor Koźmiński: High resolution and high dimensionality experiments for intrinsically disordered proteins
11.30 – 12.00 Vladimír Sklenář: Investigations of unstructured proteins using advanced multi-dimensional NMR techniques
12.00 – 12.30 Gregg Siegal: NMR in modern drug discovery
12.30 – 13.00 Harald Schwalbe: Dynamics in unfolded states of proteins and folding kinetics of novel DNA motifs
13.00 Lunch
   
  In vivo NMR
  Vladimír Sklenář (Chair)
14.30 – 15.00 Philipp Selenko: In-cell NMR in mammalian cells
15.00 – 15.30 Miquel Pons: Structure and function of cSrc unique domain studied by in vitro and in vivo NMR
15.30 – 16.00 Dmitri I. Svergun: Complementary use of small-angle X-ray scattering with NMR for macromolecular solutions
16.00 – 16.30 Coffee Break
16.30 – 17.00 Thomas F. Prisner: Structure of a bent DNA studied by a combination of NMR and EPR spectroscopy
17.00 – 17.30 Jürgen M. Schmidt: Multiple-torsion-angle dependency of protein J couplings
17.30 – 18.00 András Perczel: Structural disorder and chaperone activity of plant dehydrins by in vitro and in vivo NMR
18.00 – 18.30 Gyula Batta: Structural dynamics and cold/hot unfolding of the antifungal disulphide protein PAF
   
19.00 Concluding Remarks and Dinner